Integrin Structure and Function

Effect of progressive resistance exercise on β1 integrin and vinculin protein levels in slow-and fast-twitch skeletal muscles of male rats

Introduction: Skeletal muscle is a flexible and ever changing tissue and the role of costameric proteins in its response to different stimuli is not well defined. The aim of this study was to investigate the effect of progressive resistance exercise on β1 integrin and vinculin proteins in fast and slow twitch skeletal muscles of male rats. Methods: Twelve male Wistar rats (weight: 298±5.2 gr...

Integrin Linked Kinase (X-ILK) Function during Embryonic Development and within Adult Tissues of Xenopus laevis

Integrin linked kinase (ILK) is a serine/threonine protein kinase implicated in the phosphatidylinositol 3’kinase (PI3’K) pathway. Integrin linked kinase has been investigated in different organisms such as mammalian systems (human, mice, rat), insects (Drosophila) and nematodes (Cenorhabditis elegans), however to date little data regarding ILK research on amphibians has been reported. In...

The Effect of Laminin and Gelatin Extracellular Matrix on Short-Term Cultivation of Neonate Mouse Spermatogonial Stem Cells

Purpose: To compare the effect of laminin and gelatin on short-term culture of spermatogonial stem cells (SSCs) from neonatal mouse testes.Materials and Methods: Cell suspension containing SSCs were isolated from testes of 6 day-old mice and cultured in the presence of Glial-derived neuroterophic factor (GDNF), Epidermal Growth Factor (EGF) and Basic Fibroblastic Growth Factor (bFGF) on laminin...

Effect of Adriamycin on α1β1, α1β4, and ανβ3 Expression in Rat Endometrium in Estrus Phase

Introduction: Although the effect of adriamycin, a chemical drug used to treat cancer, is known to affect gametogenesis and ovarian function, the drug’s effect on endometrial receptivity and expression of integrin genes is unclear. To fill this gap, we aimed to investigate the effect of adriamycin on the expression of integrin genes that play a role in endometrial receptivity. Methods: A total...

P-140: Effect of Ovarian Stimulation on The Endometrial Integrin ?9, ?v, ?1, ?3 and Apoptosis in The Peri-Implantation Period

Insights into integrin-ligand binding and activation from the first crystal structure

Integrin receptors transduce bidirectional signals between extracellular adhesion molecules and intracellular cytoskeletal and signalling molecules. The structural basis of integrin signalling is unknown, but the recent publication of the first crystal structure of the extracellular domain of integrin alphaVbeta3 has provided a number of insights. In this review, previous structure-function ana...